Physiology Shorts: Dietary nitrate supplementation increases diaphragm peak power in old mice.

In this Physiology Shorts video, Associate Professor Leonardo Ferreira (University of Florida, US) discusses his latest paper about dietary nitrate supplementation increases diaphragm peak power in old mice. Find out more in the Journal of Physiology: Dietary nitrate supplementation increases…

Physiology Shorts: Dietary nitrate supplementation increases diaphragm peak power in old mice.

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In this Physiology Shorts video, Associate Professor Leonardo Ferreira (University of Florida, US) discusses his latest paper about dietary nitrate supplementation increases diaphragm peak power in old mice.

Find out more in the Journal of Physiology:
Dietary nitrate supplementation increases diaphragm peak power in old mice.
Ravi A. Kumar Rachel C. Kelley Dongwoo Hahn Leonardo F. Ferreira
598(19), pp.4357-4369
https://physoc.onlinelibrary.wiley.com/doi/10.1113/JP280027

Transcript:
Hello there, my name is Leonardo Ferreira. I am an Associate Professor in the Department of Applied Physiology and Kinesiology at the University of Florida

My research group works on mechanisms of muscle contraction and weakness in health and disease. Our goal in the lab is to identify targets and develop new therapies to improve muscle function

In our study, we tested whether dietary nitrate supplementation increases respiratory muscle force and peak power in old mice.

There were two groups of old mice that received either sodium nitrate in the drinking water or regular water. After 14 days, we measured contractile function in the diaphragm, which is a respiratory muscle

Our main findings were that the group receiving dietary nitrate had a 30% faster rate of isometric contraction and a 40% higher peak power during isotonic contractions

Our study suggests that dietary nitrate, which is readily available for human consumption in foods such as spinach and beetroot juice, might improve respiratory muscle dysfunction that contributes to morbidity and shortness of breath in the elderly or with prolonged mechanical ventilatory support

Thank you for taking the time to learn more about our study published in The Journal of Physiology. The full article was chosen as an Editor’s Choice and published in Volume 598, Issue 19. Please contact Leonardo Ferreira at ferreira@hhp.ufl.edu, if you have any questions.

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